| Name |
MITF
|
| Type |
TF
|
| Species |
Mus musculus
|
| Tissue |
Human 501 mel, WM9, and Skmel28
|
| Experiment Method |
Western blot assay,Luciferase reporter assay
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
MITF-silenced cells engage a DNA damage response (DDR) signaling pathway, leading to p53 upregulation, which is critically required for senescence entry. This study uncovers the existence of a lineage-restricted DDR/p53 signaling pathway that is inhibited
|
| Regulation Gene |
p53
|
| Year |
2010
|
| Pubmed ID |
20388797
|
| Title |
Microphthalmia-Associated Transcription Factor Controls the DNA Damage Response and a Lineage-Specific Senescence Program in Melanomas
|
| Drug |
NA
|
| Disease |
melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|