| Name |
circ_PVT1
|
| Type |
circRNA
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
siRNA transfection and SA-B-galactosidase activity,Western blot,RNA isolation and RT-qPCR,RIP
|
| Up/Down |
Down
|
| Pro/Anti |
anti
|
| Funtion Description |
Our findings indicate that the SAC-RNA CircPVT1, elevated in dividing cells and reduced in senescent cells, sequesters let-7 to enable a proliferative phenotype.
|
| Regulation Gene |
let-7
|
| Year |
2017
|
| Pubmed ID |
27928058
|
| Title |
Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
ionizing radiation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|