| Name |
MITF
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
The A375, 293A, 293T, 293FT, B16, A2059, HeLa and U87 cell lines
|
| Experiment Method |
RNA interference;The Immunoprecipitation and Western blotting and Immunohistochemical staining;The CHIP assay;luciferase assay;GST-tag proteins purification;senescence B-galactosidase staining and MTT assay
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
MITF could bind TP53 to regulate CDKN1A. Furthermore, the interaction between MITF and TP53 is dependent on AKT activity. AKT phosphorylates MITF at S510. Phosphorylated MITF S510 enhances its affinity to TP53 and promotes CDKN1A expression.Meanwhile, the
|
| Regulation Gene |
CDKN1A
|
| Year |
2016
|
| Pubmed ID |
27702651
|
| Title |
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence.
|
| Drug |
NA
|
| Disease |
melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|