| Name |
MITF-M
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Melanoma specimens
|
| Experiment Method |
immunoblotting;qRT-PCR;Soft agar colony formation assay
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
parthenolide efficiently decreases the MITF-M level. This is neither dependent on p65/NF-kB signaling nor RAF/MEK/ERK pathway activity as inhibition of MEK by GSK1120212 (trametinib) and induction of ERK1/2 activity by parthenolide itself do not interfere
|
| Regulation Gene |
MITF-M
|
| Year |
2016
|
| Pubmed ID |
26824319
|
| Title |
Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations.
|
| Drug |
Parthenolide
|
| Disease |
melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|