Details
| Name | MML-1 |
| Type | TF |
| Species | Caenorhabditis elegans |
| Tissue | C. elegans strain |
| Experiment Method | RNA interference;qRT-PCR;Western blotting; |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | MML-1 regulates nuclear localization and activity of HLH-30/TFEB, a convergent regulator of autophagy, lysosome biogenesis and longevity, by downregulating TOR signalling via LARS-1/leucyl-transfer RNA synthase. HLH-30 also upregulates MML-1 upon germline |
| Regulation Gene | TFEB |
| Year | 2016 |
| Pubmed ID | 27001890 |
| Title | Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |