A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name MYC
Type TF
Species Mus musculus
Tissue Mice
Experiment Method qRT-PCR;ChIP;Immunoblotting
Up/Down NA
Pro/Anti Anti
Funtion Description Myc haploinsufficient (Myc+/) mice exhibit increased lifespan. They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis and immunosenescence. They also appear to be more active, with a higher metabolic rate and
Regulation Gene NA
Year 2016
Pubmed ID 25619689
Title Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA