Details
| Name | NF-kB |
| Type | TF |
| Species | Mus musculus |
| Tissue | Primary calvarial osteoblasts |
| Experiment Method | qPCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | ERCC1 deficiency leads to atrophy of osteoblastic progenitors in the bone marrow stromal cell (BMSC) population. There is increased cellular senescence of BMSCs and osteoblastic cells, as characterized by reduced proliferation, accumulation of DNA damage, |
| Regulation Gene | NA |
| Year | 2013 |
| Pubmed ID | 23281008 |
| Title | DNA damage drives accelerated bone aging via an NF-kB-dependent mechanism |
| Drug | NA |
| Disease | osteoporosis |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |