Details
| Name | NF-kB |
| Type | TF |
| Species | Homo sapiens |
| Tissue | breast |
| Experiment Method | PCR,other |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | NF-kB transcription factors, which are well-known regulators of senescence. Importantly, the induction of SCN9A by an oncogenic signal or by p53 activation led to plasma membrane depolarization, which in turn, was able to induce premature senescence. |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 29446526 |
| Title | The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |