Details
| Name | Dyrk1A |
| Type | gene |
| Species | Mus musculus |
| Tissue | brian |
| Experiment Method | Histochemical detection of senescence-associated B-galactosidase;Immunocytochemical detection;Western blotting; ELISA |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, AB load in the cortex |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28647555 |
| Title | Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |