Details
| Name | NF-kB |
| Type | TF |
| Species | Mus musculus |
| Tissue | liver and gut |
| Experiment Method | Crosslinked chromatin immunoprecipitation assay;qPCR;western blotting |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | nfkb1(-/-) fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-kB, COX-2 and ROS, which stabilizes DNA damage. Preferential accumulation of telomere-dysfunctional senescent cells in nfkb1(-/-) |
| Regulation Gene | NF-kB |
| Year | 2014 |
| Pubmed ID | 24960204 |
| Title | Chronic inflammation induces telomere dysfunction and accelerates ageing in mice |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |