A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name NF-Y
Type TF
Species Homo sapiens
Tissue bladder
Experiment Method PCR
Up/Down Down
Pro/Anti NA
Funtion Description Furthermore, we found that DNA binding activity of NF-Y transcription factor, which is essential for transcription of the cdk1 and cyclin B genes and inactivated in senescent fibroblast, is significantly decreased by expression of either of p53, p63, or p
Regulation Gene cdk1 and cyclin B
Year 2001
Pubmed ID 11593387
Title p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor.
Drug NA
Disease bladder cancer
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA