| Name |
Prox1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
HCC cell lines HepG2, Hep3B, Mahlavu and SK-HEP-1
|
| Experiment Method |
ChIP,qPCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
We demonstrated that Prox1 induced senescence-like phenotype of HCC cells to reduce cell proliferation. Our results indicated that the tumor suppressor p53 is a key mediator of Prox1-induced growth suppression because Prox1 only induced senescence-like ph
|
| Regulation Gene |
Twist
|
| Year |
2013
|
| Pubmed ID |
23291986
|
| Title |
The homeobox transcription factor Prox1 inhibits proliferation of hepatocellular carcinoma cells by inducing p53-dependent senescence-like phenotype
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|