| Name |
E2F1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human prostate carcinoma (PC-3, DU145, and LNCaP),gastric carcinoma (MKN74, SNU484, SNU638, and SNU668), and breast cancer (MCF7, SK-BR3, and T48D) cells
|
| Experiment Method |
RT-PCR;Western blot and immunohistochemical analyses;Fluorescence microscopy
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Kir2.2 knockdown also induced senescence-associated B-galactosidase activity and upregulated senescence marker proteins in multiple cancer cell lines derived from different tissues, including prostate, stomach, and breast.Interestingly, knockdown of Kir2.
|
| Regulation Gene |
NA
|
| Year |
2010
|
| Pubmed ID |
20841375
|
| Title |
Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence.
|
| Drug |
NA
|
| Disease |
prostate cancer,gastric carcinoma andbreast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|