Details
| Name | Sag/Rbx2/Roc2 E3 Ubiquitin Ligase |
| Type | TF |
| Species | Mus musculus |
| Tissue | mouse model |
| Experiment Method | Immunoblotting;Immunohistochemistry Staining;RT-PCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Sag inactivation by genetic deletion remarkably suppresses cell proliferation by inducing senescence, which is associated with accumulation of p16, but not p53.Mechanistically, Sag deletion caused accumulation of Jun-B, a substrate of Sag-Fbxw7 E3 ligase |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 25622904 |
| Title | Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |