Details
| Name | SOX10 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | UACC melanoma cell line |
| Experiment Method | RNAi,qPCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Here, we report that melanoma tumor cell lines require wild-type SOX10 expression for proliferation and SOX10 haploinsufficiency reduces melanoma initiation in the metabotropic glutamate receptor 1 (Grm1(Tg)) transgenic mouse model. Stable SOX10 knockdown |
| Regulation Gene | NA |
| Year | 2013 |
| Pubmed ID | 23913827 |
| Title | SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis |
| Drug | NA |
| Disease | melanoma |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |