| Name |
SP1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human diploid fibroblasts
|
| Experiment Method |
RNAi,Western Blotting,qPCR
|
| Up/Down |
NA
|
| Pro/Anti |
Pro
|
| Funtion Description |
Sp1 knockdown led to a reduction of those genes in young human diploid fibroblast cells (HDF); Sp1 overexpression induced those genes in senescent cells. In addition, epidermal growth factor stimulation-induced p-ERK1/2 nuclear translocation and Elk-1 pho
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
23013401
|
| Title |
The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|