Details
| Name | SP1 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | human embryonic lung fibroblast cell line |
| Experiment Method | RNAi,Western blot,ChIP |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Both Sp1 RNAi and Mithramycin, a DNA intercalating agent that interferes with Sp1 and Sp3 binding activities, reduced p16 INK4a gene expression. In addition, the enhanced binding of Sp1 to p16 INK4a promoter during cellular senescence appeared to be the r |
| Regulation Gene | p16 INK5a |
| Year | 2007 |
| Pubmed ID | 17225865 |
| Title | Sp1 is essential for p17 expression in human diploid fibroblasts during senescence. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |