| Name |
SP1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
Human diploid fibroblasts (HDFs)
|
| Experiment Method |
Western blot;
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
We observed that the expression of Sp1 is down-regulated in the TRF2( delta B delta M)-induced senescence, which was mediated by ATM and p38 MAPK. In addition, overexpression of Sp1 prevented the TRF2( delta B delta M)-induced senescence. Among transcript
|
| Regulation Gene |
TRF2( delta B delta M)
|
| Year |
2016
|
| Pubmed ID |
26906205
|
| Title |
Transcription factor Sp1 prevents TRF2( delta B delta M)-induced premature senescence in human diploid fibroblasts.
|
| Drug |
NA
|
| Disease |
wheat germ agglutinin (an import inhibitor) and leptomycin B (an export inhibitor)
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|