| Name |
SP1
|
| Type |
TF
|
| Species |
Homo sapiens
|
| Tissue |
H28 and H2452 human MPM lines;LP3 and LP9 normal mesothelial cell lines;MES1-9 cell lines;All tumor samples
|
| Experiment Method |
RNA isolation, real-time quantitative reverse transcription PCR;Immunoblotting;Immunohistochemistry;ChIP
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Mithramycin depleted SP1 and activated p53, dramatically inhibiting proliferation and clonogenicity of MPM cells. IP mithramycin significantly inhibited growth of subcutaneous MPM xenografts, and completely eradicated mesothelioma carcinomatosis in 75% of
|
| Regulation Gene |
p53
|
| Year |
2016
|
| Pubmed ID |
26459178
|
| Title |
Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells.
|
| Drug |
NA
|
| Disease |
Malignant Pleural Mesothelioma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|