Details
| Name | SRSF3 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | normal human fibroblasts |
| Experiment Method | qPCR |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Here, we show that SRSF3 regulates cellular senescence, a p53-mediated process to suppress tumorigenesis, through TP53 alternative splicing. Downregulation of SRSF3 was observed in normal human fibroblasts undergoing replicative senescence, and was associ |
| Regulation Gene | p53 |
| Year | 2013 |
| Pubmed ID | 22777358 |
| Title | Downregulation of splicing factor SRSF3 induces p53B, an alternatively spliced isoform of p53 that promotes cellular senescence |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | 1 |
| Variant | NA |
| High-throughput | NA |