A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name TFAM
Type TF
Species Rat Rattus
Tissue frontal cortex samples
Experiment Method Western Blotting,qPCR
Up/Down Up
Pro/Anti NA
Funtion Description We found a 70 % increase in TFAM amount, a 25 % loss in mtDNA content, and a 35 % increase in the 4.8-kb deletion content in the aged (ad libitum-fed)AL animals with respect to the young rats. TFAM-specific binding to six mtDNA regions was analyzed by mtD
Regulation Gene NA
Year 2013
Pubmed ID 22945739
Title Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA