Details
| Name | ZEB1 |
| Type | TF |
| Species | Homo sapiens |
| Tissue | Human primary CRC tissue |
| Experiment Method | immunostaining or Western blot;Quantitative real-time PCR;chromatin immunoprecipitation (ChIP) |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | In cancer cells with mutant TP53, ZEB1 blocked the formation of senescence-associated heterochromatin foci at the onset of senescence by triggering a new regulatory cascade that involves the subsequent activation of DKK1, mutant p53, Mdm2 and CtBP to ulti |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 27965283 |
| Title | ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. |
| Drug | NA |
| Disease | colorectal cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |