Details
| Name | HDAC2 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | NA |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | Furthermore, HDAC2 knock-down promotes enhanced mitochondrial respiration and reduces levels of neurotoxic amyloid beta peptides. Collectively, our study demonstrates a role for HDAC2 in hiPSC-neuronal differentiation, highlights neuron-specific isoforms of Endophilin-B1 as a marker of differentiating hiPSC-Ns and demonstrates that HDAC2 regulates key neuronal and mitochondrial pathways in hiPSC-Ns. |
| Regulation Gene | NA |
| Year | 2021 |
| Pubmed ID | 33802405 |
| Title | Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides |
| Drug | NA |
| Disease | neurodegeneration and brain aging |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |