| Name |
Klotho
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
To accomplish this task, we designed zinc finger proteins targeting within 300 bps of the human Klotho promoter.
|
| Up/Down |
up
|
| Pro/Anti |
pro
|
| Funtion Description |
We designed the ZPF constructs either de novo from modular building blocks, or modified sequences from the natural endogenous Egr1 transcription factor backbone structure.
|
| Regulation Gene |
Klotho
|
| Year |
2020
|
| Pubmed ID |
32347987
|
| Title |
A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
null
|