| Name |
Drd3
|
| Type |
gene
|
| Species |
Mice
|
| Tissue |
NA
|
| Experiment Method |
Biochemical Analysis,qRT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
Biochemical analyses showed increased acetylation of histone marks H3K27ac and H3K18ac at the dopamine 2 receptor (D2R) gene (Drd2) promoter and increased expression of the Drd2 mRNA and D2R protein in the striatum of aged mice after administration of CI-994 at 20 mg/kg.
|
| Regulation Gene |
NA
|
| Year |
2021
|
| Pubmed ID |
34690667
|
| Title |
Dose Effects of Histone Deacetylase Inhibitor Tacedinaline (CI-994) on Antipsychotic Haloperidol-Induced Motor and Memory Side Effects in Aged Mice
|
| Drug |
CI-994
|
| Disease |
typical antipsychotic haloperidol
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|