| Name |
circ_sema4b
|
| Type |
circRNA
|
| Species |
Homo sapiens
|
| Tissue |
Lumbar disc
|
| Experiment Method |
Real-time RT-PCR, Immunoblotting,RIP,SA-B-gal staining
|
| Up/Down |
Up
|
| Pro/Anti |
anti
|
| Funtion Description |
circSEMA4B acts as a sponge and a ceRNA form miR431 in NPCs in IDD, and competes with GSK-3B and SFRP1 for miR-431 binding, thus inhibiting IL-1B-induced degenerative process in NPCs through Wnt signaling.
|
| Regulation Gene |
miR-431
|
| Year |
2018
|
| Pubmed ID |
30251693
|
| Title |
CircSEMA4B targets miR-431 modulating IL-1B-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway
|
| Drug |
NA
|
| Disease |
intervertebral disc degeneration
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|