A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name FEN1
Type gene
Species Homo sapiens
Tissue blood
Experiment Method PCR,other
Up/Down Down
Pro/Anti Pro
Funtion Description The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excis
Regulation Gene NA
Year 2018
Pubmed ID 29449545
Title Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA