| Name |
HDAC6
|
| Type |
miRNA
|
| Species |
Mice
|
| Tissue |
Bone marrow stromal cells
|
| Experiment Method |
ChIP,Luciferase reporter,transient transfection assay
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Age-related trabecular bone loss was observed in 18-month-old mice compared with 6-month-old mice. In vitro osteogenic differentiation potential of BMSCs from 18-month-old mice was weaker than 6-month-old mice, in which there was Runx2 expression inactivation in BMSCs of 18-month-old mice compared with 6-month-old mice, which was attributable to HDAC6-mediated histone hypoacetylation in Runx2 promoter.
|
| Regulation Gene |
Runx2
|
| Year |
2021
|
| Pubmed ID |
34454588
|
| Title |
HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice
|
| Drug |
NA
|
| Disease |
Senile osteoporosis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|