Details
| Name | FICZ |
| Type | gene |
| Species | Homo sapiens |
| Tissue | skin |
| Experiment Method | PCR,other |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | ICZ significantly inhibited the TGF-B-induced upregulation of mRNA and protein levels of ACTA2 and collagen I and actin polymerization in myofibroblasts. FICZ did not disturb the phosphorylation of Smad2/3. Notably, FICZ reduced the expression of pSmad2/3 |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 29102224 |
| Title | An endogenous tryptophan photo-product, FICZ, is potentially involved in photo-aging by reducing TGF-B-regulated collagen homeostasis. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |