Details
| Name | Dyrk1a |
| Type | gene |
| Species | Mice |
| Tissue | brain |
| Experiment Method | ATAC-seq, ChIP-seq |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Epigenome, transcriptome, and live-imaging analyses indicated that this gene combination induces up-regulation of embryo-associated genes and down-regulation of age-associated genes by changing their chromatin accessibility, thereby rejuvenating aged dormant NSCs to function like juvenile active NSCs. |
| Regulation Gene | NA |
| Year | 2022 |
| Pubmed ID | 34916302 |
| Title | Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |