| Name |
Ercc1
|
| Type |
gene
|
| Species |
Mice
|
| Tissue |
primary pancreatic cells
|
| Experiment Method |
Protein transfection,EV injections,Immunofluorescence,RNA-seq and qPCR,ssDNA immunoprecipitation assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we show that DNA damage leads to cellular senescence, fibrosis, loss-of-tissue architecture, and chronic pancreatitis in mice with an inborn defect in the excision repair cross complementation group 1 (Ercc1) gene.
|
| Regulation Gene |
NA
|
| Year |
2021
|
| Pubmed ID |
34797720
|
| Title |
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage
|
| Drug |
EV-delivered nuclease cargo
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|