| Name |
SHH
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Cartilage
|
| Experiment Method |
Quantitative Real-Time Reverse Transcriptase-Polymerase Chain Reaction,Western Blotting,RNAi,Detection of Apoptosis
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We show here that Sonic Hedgehog (SHH) gene expression is initiated in human normal cartilage stromal cells (NCSC) and increased in OA cartilage mesenchymal stromal cells (OA-MSCs) during aging.
|
| Regulation Gene |
L1B,IL6,CXCL1,CXCL8
|
| Year |
2021
|
| Pubmed ID |
34646822
|
| Title |
Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage
|
| Drug |
NA
|
| Disease |
osteoarthritis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|