Details
| Name | FTO |
| Type | gene |
| Species | Mice |
| Tissue | heart |
| Experiment Method | qRT-PCR,Western blotting |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | However, the levels of FTOs mRNA and protein were only significantly reduced in ischemic elderly hearts, and age-related downregulation of FTO may offset the effect of reduced Mettl3 on reduced m6A RNA level in the hearts of aging mice hearts with acute I/R injury, indicating aging-related differences in epitranscriptomic m6A regulation in hearts in response to acute I/R injury. |
| Regulation Gene | Mettl3 |
| Year | 2021 |
| Pubmed ID | 34413770 |
| Title | Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice |
| Drug | NA |
| Disease | acute myocardial ischemia/reperfusion (I/R) injury |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |