Details
| Name | PCNA |
| Type | gene |
| Species | Mice |
| Tissue | liver |
| Experiment Method | RNA-seq |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Cell cycle pathway signalling changes in males showed decreased protein and expression of key genes (Cdk2, Cdk4, Cycd and PCNA) and increased expression ofp57 at 650 vs 110 days. In females, protein and gene expression of cell growth regulators, e.g. p15 and p21, which inhibit cell cycle G1 progression, were increased. |
| Regulation Gene | NA |
| Year | 2021 |
| Pubmed ID | 34387378 |
| Title | Sexual dimorphism in liver cell cycle and senescence signalling pathways in young and old rats |
| Drug | NA |
| Disease | NA |
| Environment Factors | sexual dimorphism |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |