| Name |
C9ORF72
|
| Type |
gene
|
| Species |
Mice
|
| Tissue |
adult hippocampal neuronal and synaptic
|
| Experiment Method |
transcriptomic analysis
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Here, we showed that long-term potentiation at the dentate granule cells and long-term depression at the Schaffer collateral/commissural synapses at the area CA1 were reduced in the hippocampus of C9orf72 knockout mice
|
| Regulation Gene |
C9ORF72
|
| Year |
2020
|
| Pubmed ID |
32887666
|
| Title |
Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
null
|