Details
| Name | FoxO6 |
| Type | gene |
| Species | Mouse |
| Tissue | skin |
| Experiment Method | siRNA,adenovirus |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | To our interest, siRNA-mediated FoxO6 knockdown markedly increased melanin content and related signaling pathways in B16F10 cells even without any stimulation. On the contrary, adenovirus-mediated FoxO6 activation significantly reduced melanin content in UVB-exposed B16F10 cells, which is closely associated with the induction of antioxidant genes including MnSOD and catalase, leading to a decrease in oxidative stress. |
| Regulation Gene | FoxO6 |
| Year | 2020 |
| Pubmed ID | 32863230 |
| Title | FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |