Details
| Name | TREX-NCT |
| Type | gene |
| Species | Homo sapiens |
| Tissue | Nucleocytoplasmic |
| Experiment Method | A gene set-based approach |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | A gene set-based approach using 25 different studies showed that the TREX-NCT gene set displays distinct common downregulated patterns in senescent cells versus its expression in their nonsenescent counterparts regardless of the senescence type, such as replicative senescence (RS), tumor cell senescence (TCS), oncogene-induced senescence (OIS), stem cell senescence (SCS), progeria and endothelial cell senescence (ECS). |
| Regulation Gene | TREX-NCT |
| Year | 2020 |
| Pubmed ID | 32859952 |
| Title | Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues. |
| Drug | NA |
| Disease | cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |