Details
| Name | TMEM106B |
| Type | gene |
| Species | Mouse |
| Tissue | lysosome vacuoles |
| Experiment Method | NA |
| Up/Down | NA |
| Pro/Anti | NA |
| Funtion Description | Here, we report that TMEM106B deficiency in mice leads to accumulation of lysosome vacuoles at the distal end of the axon initial segment in motor neurons and the development of FTLD-related pathology during aging. |
| Regulation Gene | TMEM106B |
| Year | 2020 |
| Pubmed ID | 32852886 |
| Title | Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |