| Name |
Ft1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
mice;Human foreskin primary fibroblasts (HPFs), HeLa (ATCC CCL-2) and 293T (ATCC CRL-11268) cells;SH-SY5Y (ATCC CRL-2266) cells
|
| Experiment Method |
X-ray and cephalometric measurements;QPCR
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
In vitro, AKTIP/Ft1 depletion causes telomere aberrations, DNA damage, and cell senescence. AKTIP/Ft1 interacts with lamins, which control nuclear architecture and DNA function. Premature aging defects of Ft1 mutant mice include skeletal alterations and l
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30546381
|
| Title |
p53-Sensitive Epileptic Behavior and Inflammation inFt1 Hypomorphic Mice.
|
| Drug |
Epilepsy
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|