Details
| Name | BRD4 |
| Type | gene |
| Species | Mice |
| Tissue | osteoclasts |
| Experiment Method | Gene expression analysis |
| Up/Down | up |
| Pro/Anti | pro |
| Funtion Description | Inhibition of BRD4 by siBRD4 or inhibitors such as JQ-1 or I-BET762 prevented the aging of macrophages and lipid accumulation in the LPS-induced senescent macrophages by decreasing expression of SASP in autocrine and paracrine senescence. |
| Regulation Gene | siBRD4 |
| Year | 2020 |
| Pubmed ID | 32392533 |
| Title | BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. |
| Drug | null |
| Disease | atherosclerosis |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |