A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name Cx I
Type gene
Species Mammalian
Tissue heart
Experiment Method droplet digital PCR (ddPCR) and western blot
Up/Down NA
Pro/Anti NA
Funtion Description The present study follows a comparative approach to analyse complex I in heart tissue from 8 mammalian species with a longevity ranging from 3.5 to 45 years. Gene expression and protein content of selected Cx I subunits were analysed using droplet digital PCR (ddPCR) and western blot, respectively.
Regulation Gene Cx I
Year 2020
Pubmed ID 32353747
Title Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC0 predicts mammalian longevity.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput null