A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name NDUFV2 and NDUFS4 subunits
Type gene
Species Mammalian
Tissue heart
Experiment Method droplet digital PCR (ddPCR) and western blot
Up/Down NA
Pro/Anti NA
Funtion Description The present study follows a comparative approach to analyse complex I in heart tissue from 8 mammalian species with a longevity ranging from 3.5 to 46 years. Gene expression and protein content of selected Cx I subunits were analysed using droplet digital PCR (ddPCR) and western blot, respectively.
Regulation Gene NDUFV2 and NDUFS4 subunits
Year 2020
Pubmed ID 32353747
Title Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput null