Details
| Name | APOE |
| Type | gene |
| Species | Homo sapiens |
| Tissue | brain |
| Experiment Method | clinical examination, magnetic resonance imaging, and complex neuropsychological battery |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Our findings suggest that carriage of E4+BDNFMet is associated with more pronounced memory dysfunction, a typical feature of early AD, but not with structural brain changes in aMCI patients. These findings suggest that in APOEE4/BDNF Met carriers, synaptic dysfunction affecting memory may precede pronounced structural changes. |
| Regulation Gene | APOE |
| Year | 2020 |
| Pubmed ID | 31771052 |
| Title | Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in Patients with Amnestic Mild Cognitive Impairment. |
| Drug | NA |
| Disease | AD |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |