Details
| Name | AKG |
| Type | histone modification |
| Species | Rat |
| Tissue | NA |
| Experiment Method | NA |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Besides, AKG administration up-regulated Prdm16 expression, which was correlated with an increase of DNA demethylation in the Prdm16 promoter. In summary, AKG supplementation promotes beige adipogenesis and alleviates HFD-induced obesity in middle-aged mice, which is associated with enhanced DNA demethylation of the Prdm16 gene. |
| Regulation Gene | AKG |
| Year | 2020 |
| Pubmed ID | 31691468 |
| Title | Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |