Details
| Name | GATA4 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | fibroblasts |
| Experiment Method | qRT-PCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Normally, GATA4 is degraded by p62-mediated selective autophagy, but this regulation is suppressed during senescence, thereby stabilizing GATA4. GATA4 in turn activates the transcription factor NF-kB to initiate the SASP and facilitate senescence. |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 26404840 |
| Title | The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |