| Name |
Bmi1
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
HSC
|
| Experiment Method |
Chromatin immunoprecipitation-sequencing ,RNA sequence analysis
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
the sustained expression of Bmi1 augmented the multi-lineage repopulating capacity of aged HSCs. Chromatin immunoprecipitation-sequencing of Bmi1 combined with an RNA sequence analysis showed that the majority of Bmi1 direct target genes are developmental regulator genes marked with a bivalent histone domain. The sustained expression of Bmi1 strictly maintained the transcriptional repression of their target genes and enforced expression of HSC signature genes in aged HSCs.
|
| Regulation Gene |
Bmi1
|
| Year |
2020
|
| Pubmed ID |
31679686
|
| Title |
Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
null
|