Details
| Name | Lmna R225X |
| Type | miRNA |
| Species | Rat |
| Tissue | NA |
| Experiment Method | gene knockout |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | The mechanism of LMNA nonsense mutation induced cardiac conduction defects through AV node fibrosis is due to upregulated ECM gene expression upon activation of cardiac apoptosis. |
| Regulation Gene | Lmna R225X |
| Year | 2020 |
| Pubmed ID | 31668660 |
| Title | Expression of Lmna-R225X nonsense mutation results in dilated cardiomyopathy and conduction disorders (DCM-CD) in mice: Impact of exercise training. |
| Drug | NA |
| Disease | DCM |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |