Details
| Name | SIRT6 |
| Type | somatic mutation |
| Species | Homo sapiens |
| Tissue | BBB |
| Experiment Method | gene knockout |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Endothelial SIRT6 exerts a protective role in ischaemic stroke by blunting I/R-mediated BBB damage and thus, it may represent an interesting novel therapeutic target to be explored in future clinical investigation. |
| Regulation Gene | SIRT6 |
| Year | 2020 |
| Pubmed ID | 31603194 |
| Title | Endothelial SIRT6 blunts stroke size and neurological deficit by preserving blood-brain barrier integrity: a translational study. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | null |