| Name |
GCLC
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
vascular
|
| Experiment Method |
qRT-PCR,knockdown,western blot,other
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
In the aortas of IGF-1-deficient mice, there was a trend for decreased expression of Nrf2 and the Nrf2 target genes GCLC, NQO1 and HMOX1. In cultured aorta segments of IGF-1-deficient mice treated with oxidative stressors (high glucose, oxidized low-densi
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22021391
|
| Title |
Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf4-dependent antioxidant response: a novel model of vascular aging.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|