Details
| Name | GCN4 |
| Type | gene |
| Species | Saccharomyces cerevisiae |
| Tissue | yeast cells |
| Experiment Method | mRNA sequencing;Polysome profiling and Ribo-seq;Quantitative proteomics;Off-Gel electrophoresis;Mass spectrometric analysis;Western blot;ChIP-seq |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Here we show that Gcn4 acts as a repressor of protein synthesis. By analyzing the messenger RNA and protein abundance, ribosome occupancy and protein synthesis rate in various yeast strains, we demonstrate that Gcn4 is sufficient to reduce protein synthes |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28878244 |
| Title | The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |